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| Non pwodwi | 10 - [(2- (2,6-dioxopiperidin-3-il) -1,3-dioxo-2,3-dihydro-1h-isoindol-4-il) amino] asid decanoic | Fòmil estrikti |  |
| CAS No. | 2243000-24-8 | Pwa molekilè | 443.49 |
| Aparisyon | poud oswa kristal | Pwen bouyi | 714.1 ± 55.0 degre (prevwa) |
| Asay | >99.00% | Pakèt | 100mg |
| Fòmil | C23H29N3O6 |
Aplikasyon
- Pwoteyin degrader builiding blòk pomalidomid - C9 - CO2H pèmèt sentèz la nan molekil pou degradasyon pwoteyin vize ak ProtAC (proteoliz {{5} Sa a konjige gen yon Cereblon (CRBN) - rekritman ligand ak yon alkyl-chèn Crosslinker ak pendant asid karboksilik pou reyaksyon ak yon amine sou lig la sib. Paske menm ti chanjman nan ligand ak retlinkers kapab afekte Ternary fòmasyon konplèks ant sib la, E3 ligaz, ak ProtAC, anpil analòg yo prepare ekran pou degradasyon sib optimal. Lè yo itilize ak lòt blòk bilding pwoteyin ak yon gwoup karboksil pendant, sentèz paralèl ka itilize yo pi vit jenere bibliyotèk ProtAC ki prezante varyasyon nan longè retlinker, konpozisyon, ak ligas E3 ligaz.
Anbake
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